Organic nitroso compounds
Pfaltz & Bauer N-nitrosodiethylamine 98% - C | 55-18-5 | 10ml
N-nitrosodiethylamine 98% - C | 55-18-5 | 10ml
![Medchemexpress LLC L-Tryptophanamide, N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]- | 1416709-79-9 | 98.5% | 618.72 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438557-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC L-Tryptophanamide, N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]- | 1416709-79-9 | 98.5% | 618.72 | 100 MG
(R)-PR-924 is an isomer of PR-924 and can be used as an experimental control. PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. It covalently modifies proteasomal N-terminal threonine active sites, inhibits growth, and triggers apoptosis in multiple myeloma (MM) cells, demonstrating antitumor activities.
- Can be used as an experimental control.
- Selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor.
- Covalently modifies proteasomal N-terminal threonine active sites.
- Inhibits growth and triggers apoptosis in multiple myeloma (MM) cells.
- Exhibits antitumor activities.
Sigma Aldrich Fine Chemicals Biosciences N-Nitrosodiethylamine ISOPAC(R) | 55-18-5 | MFCD00013890 | 1G
N-Nitrosodiethylamine ISOPAC(R) | Mol Wt: 102.14 | 55-18-5 | MFCD00013890 | 1G
AdipoGen DETA NONOate,Chemical. CAS: 146724-94-9
DETA NONOate, AdipoGen Life Sciences. Chemical. CAS: 146724-94-9. Formula: C4H13N5O2. MW: 163.2. Nitric oxide (NO) donor. The slow release of NO allows the use in experiments investigating the effects of prolonged constant NO delivery to cells and tissues. The half-life time is 20 hours at 37?C and 56 hours at 22-25?C in 0.1M phosphate buffer, pH 7.4. Liberates 2 mol of NO per mol of parent compound. Decomposition of NONOates is nearly instantaneous at pH 5.0.
Medchemexpress LLC 4-nitroso hydrochlorothiazide-13C,15N2,d2 | 63779-86-2 | 99.3% | C613CH5D2ClN215N2O5S2 | 100 UG
4-Nitroso hydrochlorothiazide-13C,15N2,d2 is an isotopically labeled compound, primarily used for research purposes. This compound serves as a tracer and an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS. The incorporation of stable heavy isotopes like deuterium, 13C, and 15N into drug molecules is a common practice in drug development to facilitate quantitation and to study their pharmacokinetic and metabolic profiles, as deuteration can influence these aspects.
- Used as a tracer in research applications
- Functions as an internal standard for quantitative analysis
- Suitable for use with NMR, GC-MS, or LC-MS techniques
- Incorporates stable heavy isotopes for enhanced research capabilities
Medchemexpress LLC N-Nitroso-N-methylurea | 684-93-5 | 99.7% | 103.08 | 2 G
N-Nitroso-N-methylurea is a potent carcinogen, mutagen, and teratogen. It acts as a direct-acting alkylating agent that interacts with DNA, targeting multiple animal organs to cause various cancers and/or degenerative diseases. It is also a precursor in the synthesis of diazomethane.
- Potent carcinogen, mutagen, and teratogen
- Direct-acting alkylating agent that interacts with DNA
- Targets multiple animal organs to cause various cancers and/or degenerative diseases
- Precursor in the synthesis of diazomethane
- For research use only
Medchemexpress LLC N-nitrosomorpholine-d8 | 1219805-76-1 | MFCD08704880 | 99.7% | 124.17 g·mol⁻1 | C4D8N2O2 | 5 MG
N-Nitrosomorpholine-d8 is a deuterium-labeled analogue of N-nitrosomorpholine used as an isotope-labeled reference standard and internal standard for analytical testing and quantitation of nitrosamines. It is photosensitive and a potent animal carcinogen; handle with appropriate engineering controls and personal protective equipment, and consult the SDS and batch COA for safety and purity details.
- CAS number: 1219805-76-1.
- Molecular formula: C4D8N2O2.
- Molecular weight: 124.17 g·mol⁻1.
- Purity (HPLC): 99.7%.
- Appearance: Colorless to light yellow liquid.
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Intended use: isotope-labeled reference standard for analytical and quantitation applications.
Medchemexpress LLC (R)-PR-924 | 98.5% | 618.72 | 10 MG
(R)-PR-924 is an isomer of PR-924 used as an experimental control. PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor that covalently modifies proteasomal N-terminal threonine active sites. It inhibits growth and triggers apoptosis in multiple myeloma cells, demonstrating antitumor activities.
- Used as an experimental control
- Inhibits growth and triggers apoptosis in multiple myeloma cells
- Covalently modifies proteasomal N-terminal threonine active sites
- Acts as a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor
- Demonstrates antitumor activities
Medchemexpress LLC N-Nitrosomorpholine | 59-89-2 | 100.0% | 1 ML
N-Nitrosomorpholine is a photosensitive nitrosamine that is carcinogenic and can be used to construct animal cancer models. It is for research use only and not sold to patients. High doses of N-Nitrosomorpholine can cause significant cytoplasmic and nuclear changes in livers, leading to toxic damage, single-cell necrosis, loss of glycogen, and induction of giant cell production, bile duct proliferation, and fibrosis. Cirrhosis becomes obvious by the 4th week of treatment, worsening by weeks 15-20, and leading to metastatic liver cancer and death in animals by weeks 30-40.
- Photosensitive nitrosamine
- Carcinogenic agent
- Used for animal cancer model construction
- For research use only
- Induces liver toxicity and cellular changes
- Causes necrosis and fibrosis in liver tissue
- Can lead to metastatic liver cancer and mortality in animals
Medchemexpress LLC (R)-PR-924 | 1416709-79-9 | 98.5% | 618.72 | 50 MG
(R)-PR-924 is an isomer of PR-924, which can be used as an experimental control. PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. It covalently modifies proteasomal N-terminal threonine active sites, inhibits growth, and triggers apoptosis in multiple myeloma (MM) cells, also exhibiting antitumor activities.
- Selective immunoproteasome subunit LMP-7 inhibitor.
- Covalently modifies proteasomal N-terminal threonine active sites.
- Inhibits growth in multiple myeloma (MM) cells.
- Triggers apoptosis in multiple myeloma (MM) cells.
- Exhibits antitumor activities.
- Can be used as an experimental control.
Medchemexpress LLC (R)-PR-924 | 98.5% | 618.72 | 25 MG
(R)-PR-924 is an isomer of PR-924 (HY-123587) and serves as an experimental control. PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. It covalently modifies proteasomal N-terminal threonine active sites, inhibits growth, and triggers apoptosis in multiple myeloma (MM) cells, exhibiting antitumor activities.
- Serves as an experimental control
- Inhibits growth in multiple myeloma (MM) cells
- Triggers apoptosis in multiple myeloma (MM) cells
- Exhibits antitumor activities
- Covalently modifies proteasomal N-terminal threonine active sites
- Selective immunoproteasome subunit LMP-7 inhibitor
- IC50 of 22 nM for LMP-7 inhibition
Medchemexpress LLC Pr-924 | 1416709-79-9 | 98.9% | 618.72 | C37H38N4O5 | 25MG
PR-924 is a selective tripeptide epoxyketone inhibitor targeting the immunoproteasome subunit LMP-7. It covalently modifies proteasomal N-terminal threonine active sites, exhibits low-nanomolar potency (IC50 ≈ 22 nM), and has demonstrated antiproliferative and pro-apoptotic activity in multiple myeloma models. Intended for research use only.
- Selective LMP-7 inhibition with low-nanomolar potency (IC50 ≈ 22 nM).
- Covalent, irreversible mechanism of action for target engagement.
- Demonstrated antiproliferative and pro-apoptotic activity in preclinical models.
- High purity to support reproducible experimental results.
- Available in multiple solid and solution formats for flexible dosing.
- Supplied for research use only; not for human use.
Sigma Aldrich Fine Chemicals Biosciences N-Butyl-N-(4-hydroxybutyl)nitrosamine ISOPAC(R), >=90% (GC) | 3817-11-6 | 1G
N-Butyl-N-(4-hydroxybutyl)nitrosamine ISOPAC(R), >=90% (GC) | Purity: >=90% (GC) | Mol Wt: 174.24 | 3817-11-6 | 1G